Bone Marrow Transplant in Turkey

A bone marrow transplant is a procedure performed to replace damaged or destroyed bone marrow stem cells with healthy bone marrow stem cells. Usually done to restore the immune system or treat blood and marrow diseases such as cancer (leukemia, lymphoma, multiple myeloma), sickle cell anaemia, Myelodysplasia and others. Bone marrow transplants also can be used to treat noncancerous conditions, including aplastic anemia, congenital deficiencies of the immune system and thalassemia major. Bone marrow transplants have also been used to treat other types of cancer, including breast cancer and kidney cancer.

Different types of bone marrow transplants,

There are three different categories of bone marrow transplants depending on who the donor is,

Autologous bone marrow transplant. The donor is the patient himself or herself. Stem cells are taken from the patient either by bone marrow harvest or apheresis (a process of collecting peripheral blood stem cells), frozen, and then given back to the patient after intensive treatment.

Allogeneic bone marrow transplant. The donor shares the same genetic type as the patient. Stem cells are taken either by bone marrow harvest or apheresis from a genetically matched donor, usually a brother or sister. Some cases genetically matched marrow or stem cells are taken from an unrelated donor.

Umbilical cord blood transplant. Stem cells are taken from an umbilical cord immediately after delivery of an infant.  The stem cells are tested, typed, counted, and frozen until they are needed for a transplant.

Bone marrow transplantation cost in Turkey

Autologous Bone marrow transplant:  USD 45,000 – USD 55,000

Allogeneic Bone marrow transplant:  USD 65000 – USD 85000

Why Turkey for Bone marrow transplantation

Turkey is leading destination for highly advanced healthcare services, catering to patients from all parts of the world. The increasing demand of high quality medical services at affordable prices has made Turkey a popular medical travel destination.  Bone marrow transplantation in Turkey is performed by highly experienced Doctors team with most advanced technology in the world.  Bone marrow transplantation in Turkey is safe, effective and has high success rate. Bone marrow transplantation is done at Istanbul, Ankara, Antalya and other major cities. Bone marrow transplantation in Turkey is available for adult as well as pediatric patients.

High Quality Medical Services: Joint Commission Inter national (JCI) accredited hospitals with dedicated BMT units which are especially designed for patients who undergo stem cell transplant. International strict protocols to ensure the effective and successful treatment of the patient.

Qualified doctors: Bone marrow transplantation team includes hematologists, hemato-oncologists and other specialists (such as oncologists in case of cancer patients) work together to conduct bone marrow transplant based on the patient’s need. All involved Doctors are highly experienced in performing Bone marrow transplantation.

Affordable Bone marrow transplantation Cost: Cost of Bone marrow transplantation in Turkey is Affordable compared to Europe, USA, UK, Singapore, Australia, etc.

High Success rate of Bone marrow transplantation: Highly experienced Doctors, Best available Technology and stringently followed safety guidelines for post-operative care of the patient, results in high success rate for Bone marrow transplantation in Turkey.

Best Hospitals for Bone Marrow Transplant in Turkey

Bone Marrow Transplant cost in Turkey Hospitals

Diseases that can be cured using Bone Marrow Transplant in Turkey

Malignant disease :

• Multiple myeloma
• Relapsed Hodgkins Disease
• Relapsed Non Hodgkins Lymphoma (NHL)
• Neuroblastoma
• Relapsed Ewings Sarcoma
• Metastatic Ewings Sarcoma
• Metastatic Germ cell tumors
• Medulloblastoma, other brain tumors
• Other solid malignancy
• MDS
• AML
• High Risk ALL
• Relapsed or Refractory AML/ALL
• CML
• Refractory Lymphomas
• Myeloproliferative Neoplasms (MPN)

Non-Malignant disease :

• Severe Autoimmune Diseases
• Multiple Sclerosis
• Aplastic Anemia
• Thalassemia
• Severe Immunodeficiency disorders
• Inherited Metabolic disorders

Donor for Bone Marrow Transplants

 Ideal donor for Bone Marrow Transplants:

• The best possible chance to get the HLA typing match is from siblings. In about 30% of the cases the patient will get a good match from their sisters / brothers. So siblings are the first one to check for HLA match.
• If the patient is not getting suitable HLA match with their siblings then the next possibility is the half matched HLA from their parents or children. Half of the HLA markers come from the mother and half from father. It is unlikely that other family members HLA will match the patient.

Outside Donor for Bone Marrow Transplants:

• If the patient does not have suitable match in the family, then transplant team may look for an unrelated donor. In this case stem cell has to be procured from domestic/ international registry.
• HCG – The Specialist in Cancer Care is tied up with all national and International Bone marrow registry to perform quick search for the suitable donor.
• Typically it takes 2 working days to find out whether any suitable donor match is available in the donor registry or not.

Approximately 90% donations are made via nonsurgical technique doctors call PBSC, for peripheral blood stem cell donation. In this technique, blood- forming cells are removed from the donor’s blood via a needle stuck in arm.

Common Diseased Bone Marrow Transplants are used,

Acute myeloblastic leukemia

• In acute myeloblastic leukemias that develop after myelodysplastic syndrome.
• In patients with acute myeloblastic leukemia without any t(8;21), t(15;17), (Inv 16) abnormality.
• In patients who do not respond to remission induction therapy.
• In patients with Flt-3positive acute myeloblastic leukemia.

Acute lymphoblastic leukemia

• In patients with unfavorable cytogenetic finding such as Philadelphia chromosome, 11q23 positive.
• In patients with leukocyte counts in excess of 30-50 thousand microliters.
• In patients with central nervous system or testicle involvement.
• In patients who do not respond to initial remission induction therapy.

Myelodysplastic syndrome

• In patients with blast rate >5%.
• In patients with Intermediate 1, Intermediate 2 or a higher risk score.
• In patients with cytopenia in more than one sequence

Non-Hodgkin’s lymphomas

• 1. In diffuse large cell lymphomas:
• Upon first relapse (recurrence of the disease after the treatment)
• Upon first remission in patients with high, high intermediate risk.
• 2. Mantle cell lymphoma; after initial treatment
• 3. Follicular lymphoma;
• Patients who do not respond sufficiently to initial treatment.
• Patients with first remission shorter than > 12 months
• Patients with a 2nd relapse (disease recurring).
• Patients experiencing conversion into diffuse large B cell lymphoma.
• Hodgkin’s lymphoma
• Patients who fail to start remission with initial treatment.
• Patients who respond to initial treatment, but later experience a relapse.
• Multiple myeloma
• Subsequent to initial treatment (after reduction of protein M with 2-4 courses of chemotherapy).

What are bone marrow transplantation suitability criteria?

• Criteria for Autologous Stem Cell Transplant (Multiple Myeloma, Hodgkin’s and Non-Hodgkin’s Lymphoma etc.):
• Heart ejection fraction > 50%,
• Liver function tests should not exceed twic the normal limits,
• Lung function tests: DLCO > 60 %,
• Good patient performance.

Criteria for Myeloablative Allogeneic Stem Cell Transplant:

• Age < 55,
• HLA matching sibling (6 out of 6 or 5 out of 6 markers),
• Heart ejection fraction > 50%,
• Normal liver function tests,
• Lung function tests; DLCO > 60%.

Criteria for Non Myeloablative (Reduced Dose Regime) Allogeneic Stem Cell Transplant:

• Age < 65,
• HLA matching sibling or relative.

Top Bone Marrow Transplant Hospital Details in Turkey

Anadolu Medical Center:  Bone Marrow Transplantation Center

The Bone Marrow (Stem Cell) Transplantation Center of Anadolu Medical Center features a Bone Marrow Outpatient Clinic, Bone Marrow Inpatient Clinic, HLA Typing Laboratory, Hemapheresis Laboratory, Cryopreservation and Stem Cell Processing Laboratory Molecular level diagnostics of cancer are provided through flow cytometry and PCR and the efficiency of the treatment is monitored. Our Bone Marrow (Stem Cell) Inpatient Department has 22 beds on two floors. First of all, there is a special section at the entrance of each patient room between the room and the corridor.

Prof. Dr Zafer Gülbaş (head of the department) is considered one of the most experienced Onco-hematologists in Turkey. He has been practicing for more than 30 years and during his medical career has repeatedly been trained in renowned medical centers in the US and Europe. The Medical Center has access to the International Register of Bone Marrow Donors. The success of transplants according to statistics is 95%.

Bone Marrow Transplant Cost at Anadolu Medical Center:

Autologous Bone Marrow Transplant average cost in Anadolu Medical Center: $60,000

Allogeneic Bone Marrow Transplant average cost in Anadolu Medical Center: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Cumhuriyet Mah, 2255. Sk. No: 3, 41400 Gebze/Kocaeli, Turkey

Memorial Hospital Bone Marrow Transplantation Center

Memorial Healthcare Group which has an international reputation in Organ Transplantation offers service via Memorial Bone Marrow Transplantation Center in accordance with its vision of being a reference center in many branches in Turkey. The unit which aims to meet the needs for bone marrow transplantation of the patients who come from many other countries along with Istanbul and Turkey has all the facilities deriving from today’s technology.

Having 3 different Bone Marrow Transplantation centers in 3 different cities in Turkey gives the patients an advantage of choice and timeline flexibility.

Besides providing the international standards on bone marrow transplantation, the center offers all the services needed by the patients. Those who have blood disorders such as multiple myeloma (malignant bone marrow disease caused by plasma cells), lymphoma (hematological lymph node cancer), acute leukemia (cancer of the blood) and chronic leukemia, aplastic anemia can have bone marrow transplant in the center where the treatment processes are conducted within a multidisciplinary structure.

Available Doctors

Doctors of Department
Memorial Sisli Hospital
Assoc. Prof. M. Teoman YANMAZ
Assoc. Prof. Şebnem İZMİR GÜNER
Memorial Bahçelievler Hospital
Prof. Ali İrfan Emre TEKGÜNDÜZ
MD Ömür KAYIKÇI
Memorial Ankara Hospital
Prof. Ferit AVCU
Prof. Türker ÇETİN

Bone Marrow Transplant Cost at Memorial Hospital :

Autologous Bone Marrow Transplant average cost in Memorial Hospital: $60,000

Allogeneic Bone Marrow Transplant average cost in Memorial Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Burhaniye Mah. Nagehan Sk. A Apt. No: 4 A / 1, 34476 ‐ Üsküdar / İstanbul

Medical Park Hospitals Bone Marrow Transplantation Center

A treatment program, providing both service and training at international standards, is offered in stem cell and bone marrow transplantations in adult and children at Bone Marrow Transplantation Departments within the scope of Medical Park Hospitals Group. Transplantation Programs include clinical research in high dose chemotherapy and long-term outcome for bone marrow transplantations. The Bone Marrow Transplantation Multidisciplinary Team is comprised of physicians, nurses, pharmacists, therapists, social workers and administrators specializing in all aspects of stem cell transplantation. The Bone Marrow Transplantation Program is heavily supported by specialty programs based in the Divisions of Intensive Care Unit, Pulmonary Medicine, Infectious Diseases, Renal Medicine and other specialty services of the Medical Center. Our Bone Marrow Transplantation centers are certified by Ministry of Health and EBMT for conduct of autologous, allogeneic, matched-unrelated and reduced intensity transplantations. Our Units are also certified as Unrelated Donor Harvests by EBMT. At these centers, patient rooms and corridors are equipped with a HEPA Filtering system, which reduces the risk of airborne infections.

Adult Bone Marrow Transplant Centers

Medical Park Antalya Hospital Complex

Medical Park Göztepe Hospital Complex

Medical Park Bahçelievler Hospital

Medical Park İzmir Hospital

Pediatric Bone Marrow Transplant Centers

Medical Park Antalya Hospital Complex

Medical Park Göztepe Hospital Complex

Medical Park Bahçelievler Hospital

Medical Park Samsun Hospital

Bone Marrow Transplant Cost at Medical Park Hospital :

Autologous Bone Marrow Transplant average cost in Medical Park Hospital: $60,000

Allogeneic Bone Marrow Transplant average cost in Medical Park Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Otakçılar Cd. No:78 Flat Ofis Aqua Court E Blok 3. Kat Eyüp – İstanbul

Languages Spoken : ​​ العربية, Azerbaycanca, Deutsch, English, فارسی, Pусский, Türkçe, O’zbek, Türkmençe, Français, Magyar, ქართული, Română, Bosanski jezik, Srpski jezik, Српски језик, Македонски јазик, Gjuha shqipe, қaзaқшa, Polish, Italian.

Acibadem Hospital Bone Marrow Transplantation Center

Transplanted stem cells are prepared in licensed GMP laboratory of Acıbadem Healthcare Group; and all cells are analyzed for vitality, count and activity prior to the transplantation procedure.

• Haploidentical transplants at Acıbadem Hospital are performed by alpha-beta T-cell depletion to reduce the lethal complication of Graft versus host disease and hence reduce patient loss as a result of this complication.
• CD19 positive cells are also depleted to avoid post transplant lethal Epstein Barr Virus (EBV) infection. This also avoids EBV related lethal Lymhoproliferative disease.
• Mesenchymal stem cell support which helps to reduce Graft versus host disease, aid engraftment and help speedy recovery of immune function is provided for all Allogeneic transplants including Full matched. Matched Unrelated and Haploidentical transplantation.
• CD45Ra depleted donor T-cells are routinely infused to all Haploidentical transplantation patients in order to boost the antiviral immunity.
• Virus specific T-cells are routinely provided for resistant CMV, EBV, BK virus, Adenovirus and Herpes Simplex Virus activation in the patient. This procedure can be life saving at times.
• Altunizade Acıbadem Hospital utilizes the latest transplant technologies and with the aid of an experienced clinical transplant team providing the patient with the best chance of survival.
• Altunizade Acıbadem Hospital presents economical transplant packages to establishments and is highly competitive in comparison with Western Europe and USA.

Bone Marrow Transplant Cost at Acibadem  Hospital :

Autologous Bone Marrow Transplant average cost in Acibadem Hospital: $60,000

Allogeneic Bone Marrow Transplant average cost in Acibadem Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Altunizade Mah. Yurtcan Sok. No: 1 Üsküdar İstanbul İstanbul 34662 Turkey

Medipol Hospital Bone Marrow Transplantation Center

Medipol University Hospital taking sure steps towards becoming an important reference center in the field of health, also serves with Bone Marrow- Stem Cell Transplantation Center. The unit aims to meet the necessity of bone marrow transplantation in patients not only from Turkey but also around the world has all the facilities of latest technology.

Medipol University Hospital Bone Marrow- Stem Cell Transplantation Center consists of outpatient, inpatient department, modern laboratories and intensive care unit.

In addition to ensuring the international standards by Strong academics taking part in the bone-marrow stem cell transplantation center; -all services are provided as needed by the patient.

Bone Marrow Transplant Cost at Medipol University  Hospital :

Autologous Bone Marrow Transplant average cost in Medipol University Hospital: $60,000

Allogeneic Bone Marrow Transplant average cost in Medipol University Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar 34214 İstanbul, Turkey

Hisar Hospital Bone Marrow Transplantation Center

A medical team consisting of a professor of hematology experienced in stem cell transplantation, a specialist medical doctor, a biologist with expertise in the field of apheresis and bone marrow cryopreservation, and experienced nurses and personnel are responsible for providing the highest standards of care in our bone marrow transplantation unit with 20 inpatient beds.

All rooms are for a single occupancy and equipped with world-standard HEPA filters that filter dust and microbes from the air. The content and quality of the food served to our patients are continuously checked by an experienced dietician, particularly with regard to neutropenic diet (free of microbes).

Our specialist psychologist provides the required psychological support to our patients before and after the transplantation. Also, a pharmaceutist is responsible for the preparation and storage of chemotherapeutic and other pharmaceutical agents.

Bone Marrow Transplant Cost at Hisar Hospital :

Autologous Bone Marrow Transplant average cost in Hisar Hospital: $60,000

Allogeneic Bone Marrow Transplant average cost in Hisar Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Saray Mah. Site Yolu Cad. No:7 34768 Ümraniye / İstanbul/Turkey