Immune deficiencies in Turkey

Primary immunodeficiency diseases (PI) are a group of more than 400 rare, chronic disorders in which part of the body’s immune system is missing or functions improperly. While not contagious, these diseases are caused by hereditary or genetic defects, and, although some disorders present at birth or in early childhood, the disorders can affect anyone, regardless of age or gende

Many people with primary immunodeficiency are born missing some of the body’s immune defenses or with the immune system not working properly, which leaves them more susceptible to germs that can cause infections.

Immune deficiencies Treatment cost in Turkey

Best Hospitals for Immune deficiencies Treatment in Turkey

Immune deficiencies Bone Marrow Transplant cost in Turkey Hospitals

Common Diseased Bone Marrow Transplants are used,

Acute myeloblastic Immune deficiencies

• In acute myeloblastic Immune deficienciess that develop after myelodysplastic syndrome.
• In patients with acute myeloblastic Immune deficiencies without any t(8;21), t(15;17), (Inv 16) abnormality.
• In patients who do not respond to remission induction therapy.
• In patients with Flt-3positive acute myeloblastic Immune deficiencies.

Acute lymphoblastic Immune deficiencies

• In patients with unfavorable cytogenetic finding such as Philadelphia chromosome, 11q23 positive.
• In patients with leukocyte counts in excess of 30-50 thousand microliters.
• In patients with central nervous system or testicle involvement.
• In patients who do not respond to initial remission induction therapy.

Myelodysplastic syndrome

• In patients with blast rate >5%.
• In patients with Intermediate 1, Intermediate 2 or a higher risk score.
• In patients with cytopenia in more than one sequence

Non-Hodgkin’s lymphomas

• 1. In diffuse large cell lymphomas:
• Upon first relapse (recurrence of the disease after the treatment)
• Upon first remission in patients with high, high intermediate risk.
• 2. Mantle cell lymphoma; after initial treatment
• 3. Follicular lymphoma;
• Patients who do not respond sufficiently to initial treatment.
• Patients with first remission shorter than > 12 months
• Patients with a 2nd relapse (disease recurring).
• Patients experiencing conversion into diffuse large B cell lymphoma.
• Hodgkin’s lymphoma
• Patients who fail to start remission with initial treatment.
• Patients who respond to initial treatment, but later experience a relapse.
• Immune deficiencies
• Subsequent to initial treatment (after reduction of protein M with 2-4 courses of chemotherapy).

What are bone marrow transplantation suitability criteria?

• Criteria for Autologous Stem Cell Transplant (Immune deficiencies, Hodgkin’s and Non-Hodgkin’s Lymphoma etc.):
• Heart ejection fraction > 50%,
• Liver function tests should not exceed twic the normal limits,
• Lung function tests: DLCO > 60 %,
• Good patient performance.

Criteria for Myeloablative Allogeneic Stem Cell Transplant:

• Age < 55,
• HLA matching sibling (6 out of 6 or 5 out of 6 markers),
• Heart ejection fraction > 50%,
• Normal liver function tests,
• Lung function tests; DLCO > 60%.

Criteria for Non Myeloablative (Reduced Dose Regime) Allogeneic Stem Cell Transplant:

• Age < 65,
• HLA matching sibling or relative.

Top Immune deficiencies Hospitals in Turkey

1. Anadolu Medical Center: Bone Marrow Transplantation Center

The Bone Marrow (Stem Cell) Transplantation Center of Anadolu Medical Center features a Bone Marrow Outpatient Clinic, Bone Marrow Inpatient Clinic, HLA Typing Laboratory, Hemapheresis Laboratory, Cryopreservation and Stem Cell Processing Laboratory Molecular level diagnostics of cancer are provided through flow cytometry and PCR and the efficiency of the treatment is monitored. Our Bone Marrow (Stem Cell) Inpatient Department has 22 beds on two floors. First of all, there is a special section at the entrance of each patient room between the room and the corridor.

Prof. Dr Zafer Gülbaş (head of the department) is considered one of the most experienced Onco-hematologists in Turkey. He has been practicing for more than 30 years and during his medical career has repeatedly been trained in renowned medical centers in the US and Europe. The Medical Center has access to the International Register of Bone Marrow Donors. The success of transplants according to statistics is 95%.

Bone Marrow Transplant Cost at Anadolu Medical Center:

Immune deficiencies Autologous Bone Marrow Transplant average cost in Anadolu Medical Center: $60,000

Immune deficiencies Allogeneic Bone Marrow Transplant average cost in Anadolu Medical Center: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Cumhuriyet Mah, 2255. Sk. No: 3, 41400 Gebze/Kocaeli, Turkey

2. Memorial Hospital Bone Marrow Transplantation Center

Memorial Healthcare Group which has an international reputation in Organ Transplantation offers service via Memorial Bone Marrow Transplantation Center in accordance with its vision of being a reference center in many branches in Turkey. The unit which aims to meet the needs for bone marrow transplantation of the patients who come from many other countries along with Istanbul and Turkey has all the facilities deriving from today’s technology.

Having 3 different Bone Marrow Transplantation centers in 3 different cities in Turkey gives the patients an advantage of choice and timeline flexibility.

Besides providing the international standards on bone marrow transplantation, the center offers all the services needed by the patients. Those who have blood disorders such as Immune deficiencies (malignant bone marrow disease caused by plasma cells), lymphoma (hematological lymph node cancer), acute Immune deficiencies (cancer of the blood) and chronic Immune deficiencies, Immune deficiencies can have bone marrow transplant in the center where the treatment processes are conducted within a multidisciplinary structure.

Available Doctors

Doctors of Department
Memorial Sisli Hospital
Assoc. Prof. M. Teoman YANMAZ
Assoc. Prof. Şebnem İZMİR GÜNER
Memorial Bahçelievler Hospital
Prof. Ali İrfan Emre TEKGÜNDÜZ
MD Ömür KAYIKÇI
Memorial Ankara Hospital
Prof. Ferit AVCU
Prof. Türker ÇETİN

3. Bone Marrow Transplant Cost at Memorial Hospital :

Immune deficiencies Autologous Bone Marrow Transplant average cost in Memorial Hospital: $60,000

Immune deficiencies Allogeneic Bone Marrow Transplant average cost in Memorial Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Burhaniye Mah. Nagehan Sk. A Apt. No: 4 A / 1, 34476 ‐ Üsküdar / İstanbul

4. Medical Park Hospitals Bone Marrow Transplantation Center

A treatment program, providing both service and training at international standards, is offered in stem cell and bone marrow transplantations in adult and children at Bone Marrow Transplantation Departments within the scope of Medical Park Hospitals Group. Transplantation Programs include clinical research in high dose chemotherapy and long-term outcome for bone marrow transplantations. The Bone Marrow Transplantation Multidisciplinary Team is comprised of physicians, nurses, pharmacists, therapists, social workers and administrators specializing in all aspects of stem cell transplantation. The Bone Marrow Transplantation Program is heavily supported by specialty programs based in the Divisions of Intensive Care Unit, Pulmonary Medicine, Infectious Diseases, Renal Medicine and other specialty services of the Medical Center. Our Bone Marrow Transplantation centers are certified by Ministry of Health and EBMT for conduct of autologous, allogeneic, matched-unrelated and reduced intensity transplantations. Our Units are also certified as Unrelated Donor Harvests by EBMT. At these centers, patient rooms and corridors are equipped with a HEPA Filtering system, which reduces the risk of airborne infections.

Adult Bone Marrow Transplant Centers

Medical Park Antalya Hospital Complex

Medical Park Göztepe Hospital Complex

Medical Park Bahçelievler Hospital

Medical Park İzmir Hospital

Pediatric Bone Marrow Transplant Centers

Medical Park Antalya Hospital Complex

Medical Park Göztepe Hospital Complex

Medical Park Bahçelievler Hospital

Medical Park Samsun Hospital

Bone Marrow Transplant Cost at Medical Park Hospital :

Immune deficiencies Autologous Bone Marrow Transplant average cost in Medical Park Hospital: $60,000

Immune deficiencies Allogeneic Bone Marrow Transplant average cost in Medical Park Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Otakçılar Cd. No:78 Flat Ofis Aqua Court E Blok 3. Kat Eyüp – İstanbul

Languages Spoken : العربية, Azerbaycanca, Deutsch, English, فارسی, Pусский, Türkçe, O’zbek, Türkmençe, Français, Magyar, ქართული, Română, Bosanski jezik, Srpski jezik, Српски језик, Македонски јазик, Gjuha shqipe, қaзaқшa, Polish, Italian.

5. Acibadem Hospital Bone Marrow Transplantation Center

Transplanted stem cells are prepared in licensed GMP laboratory of Acıbadem Healthcare Group; and all cells are analyzed for vitality, count and activity prior to the transplantation procedure.

• Haploidentical transplants at Acıbadem Hospital are performed by alpha-beta T-cell depletion to reduce the lethal complication of Graft versus host disease and hence reduce patient loss as a result of this complication.
• CD19 positive cells are also depleted to avoid post transplant lethal Epstein Barr Virus (EBV) infection. This also avoids EBV related lethal Lymhoproliferative disease.
• Mesenchymal stem cell support which helps to reduce Graft versus host disease, aid engraftment and help speedy recovery of immune function is provided for all Allogeneic transplants including Full matched. Matched Unrelated and Haploidentical transplantation.
• CD45Ra depleted donor T-cells are routinely infused to all Haploidentical transplantation patients in order to boost the antiviral immunity.
• Virus specific T-cells are routinely provided for resistant CMV, EBV, BK virus, Adenovirus and Herpes Simplex Virus activation in the patient. This procedure can be life saving at times.
• Altunizade Acıbadem Hospital utilizes the latest transplant technologies and with the aid of an experienced clinical transplant team providing the patient with the best chance of survival.
• Altunizade Acıbadem Hospital presents economical transplant packages to establishments and is highly competitive in comparison with Western Europe and USA.

Bone Marrow Transplant Cost at Acibadem Hospital :

Immune deficiencies Autologous Bone Marrow Transplant average cost in Acibadem Hospital: $60,000

Immune deficiencies Allogeneic Bone Marrow Transplant average cost in Acibadem Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Altunizade Mah. Yurtcan Sok. No: 1 Üsküdar İstanbul İstanbul 34662 Turkey

6. Medipol Hospital Bone Marrow Transplantation Center

Medipol University Hospital taking sure steps towards becoming an important reference center in the field of health, also serves with Bone Marrow- Stem Cell Transplantation Center. The unit aims to meet the necessity of bone marrow transplantation in patients not only from Turkey but also around the world has all the facilities of latest technology.

Medipol University Hospital Bone Marrow- Stem Cell Transplantation Center consists of outpatient, inpatient department, modern laboratories and intensive care unit.

In addition to ensuring the international standards by Strong academics taking part in the bone-marrow stem cell transplantation center; -all services are provided as needed by the patient.

Bone Marrow Transplant Cost at Medipol University Hospital :

Immune deficiencies Autologous Bone Marrow Transplant average cost in Medipol University Hospital: $60,000

Immune deficiencies Allogeneic Bone Marrow Transplant average cost in Medipol University Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar 34214 İstanbul, Turkey

7. Hisar Hospital Bone Marrow Transplantation Center

A medical team consisting of a professor of hematology experienced in stem cell transplantation, a specialist medical doctor, a biologist with expertise in the field of apheresis and bone marrow cryopreservation, and experienced nurses and personnel are responsible for providing the highest standards of care in our bone marrow transplantation unit with 20 inpatient beds.

All rooms are for a single occupancy and equipped with world-standard HEPA filters that filter dust and microbes from the air. The content and quality of the food served to our patients are continuously checked by an experienced dietician, particularly with regard to neutropenic diet (free of microbes).

Our specialist psychologist provides the required psychological support to our patients before and after the transplantation. Also, a pharmaceutist is responsible for the preparation and storage of chemotherapeutic and other pharmaceutical agents.

Bone Marrow Transplant Cost at Hisar Hospital :

Immune deficiencies Autologous Bone Marrow Transplant average cost in Hisar Hospital: $60,000

Immune deficiencies Allogeneic Bone Marrow Transplant average cost in Hisar Hospital: $95,000

Kindly note that Bone Marrow Transplant cost slightly varies based on Medical and Age factors.

Address: Saray Mah. Site Yolu Cad. No:7 34768 Ümraniye / İstanbul/Turkey