CAR T-Cell Therapy For Lymphoma – A Groundbreaking Treatment

Every year, around 90,000 people are diagnosed with lymphoma, an aggressive cancer of the lymphatic system. Despite advances in treatments, patients can survive for no more than a few years after diagnosis. However, CAR T-cell therapy is a novel treatment showing remarkable results for lymphoma. 

CAR T-cell therapy for lymphoma is a ground-breaking immunotherapy revolution. It uses the immune cells of the patients to treat lymphoma. This treatment has become a beacon of hope for patients with non-Hodgkin lymphoma (NHL) that has relapsed or become refractory (unresponsive to other therapies). 

This novel treatment is approved by the Food and Drug Administration (FDA) and is considered fully safe. Lymphoma patients who haven’t responded to any other treatments so far are eligible to receive it. Clinical trials show that it produces impressive response rates in patients whose cancer relapses after standard chemotherapy and stem cell transplants. 

CAR T-cell therapy for lymphoma is currently available in some specific hospitals in India, Turkey, Israel, Singapore, and Spain. Find out all about its cost, hospitals, and success rate.

How Does CAR T-Cell Therapy Work For Lymphoma?

Chimeric Antigen Receptor T cell therapy (CAR-T) is a type of immunotherapy that modifies the T-cells of the lymphoma patient to detect and destroy cancer. T cells are white blood cells that attack foreign or cancer cells. CAR-T therapy boosts the effectiveness of T cells to stop this cancer. 

In CAR T-cell therapy for lymphoma, T cells are removed from patients. They are genetically modified or re-engineered to produce CARs. The new CAR T cells are grown in a laboratory until their number increases to a billion. They are then infused back into the patient. CAR T cells multiply inside the patient’s body and attack the lymphoma cells.

The major approved CAR T-cell therapies for lymphoma are Yescarta, Tecartus, Breyanzi, and Kymriah.

The Success Rate Of CAR T-Cell Therapy For Lymphoma

The success rate of CAR T-cell therapy for lymphoma depends on the kind of lymphoma being treated. Complete response rates ranging from 44% to 91% have been observed after CAR T-cell therapy for non-Hodgkin lymphoma. Patients have also achieved complete remission. The remission rates vary from 28% to 68%. 

In another study of 43 patients with non-Hodgkin lymphoma, 58% of those treated with CAR T-cell therapy had a complete response 76% of patients found that CAR T-cell therapy sent lymphoma into a lasting remission. 

This therapy is also associated with lower relapse rates. It has shown longer progression-free survival in patients with B-cell lymphomas. 

Studies even show that CAR T-cell therapy can benefit older patients, those over 65 years. According to Peter Riedell, MD, at the University of Chicago Medicine, elderly patients with lymphoma have medical problems and functional restrictions, but they can also be safely administered CAR T-cell therapy, which can lead to encouraging long-term outcomes.

Side Effects Of Car T-Cell Therapy For Lymphoma

CAR T-cell therapy is effective yet has some side effects, which the patient should be aware of. These include:

• Cytokine Release Syndrome or CRS – It is a common side-effect and manifests as fever, chills, rapid heart rate, low blood pressure, and headache.
• Nervous system problems – The chemicals released by CAR T-cells affect the nervous system. They give side effects like headaches, speech issues, confusion, tremors, and difficulty in moving the body.
• Low blood count results when CAR T-cell therapy is given with chemotherapy. A very low blood count requires the patient to have a blood transfusion.
• The risk of developing infections increases when the patient has a low blood count and antibodies. 

Who Is Eligible For CAR T-Cell Therapy For Lymphoma?

The following lymphoma patients are eligible for CAR T-cell therapy.

• Confirmed diagnosis of primary mediastinal large B-cell lymphoma.
• Patients who are diagnosed with B-cell lymphoma, or transformed follicular lymphoma to Diffuse large B-cell lymphoma (DLBCL) that has relapsed are also eligible.
• Patients whose lymphoma has not responded to two prior lines of systemic therapy are eligible. These previous therapies should have been over a year long.
• Patients with DLBCL who have relapsed or have not responded to any first-line treatment and cannot undergo stem cell transplant are eligible for CAR T treatment.
• Patients with follicular lymphoma have relapsed or have shown no response to prior lines of treatment.
• Patients with mantle cell lymphoma have shown no response or have relapsed after the first line of treatment.

How Much Does CAR T-Cell Therapy For Lymphoma Cost In India

CAR T-cell therapy for lymphoma costs around $78,000 in India. This cost is distributed in the following way.

CAR T-Cell Therapy for Lymphoma – Hospitals and Doctors in India

In India, CAR T-cell therapy for lymphoma is available in the following hospitals:

• Tata Memorial Hospital, Mumbai
• Apollo Hospital, Chennai
• Max Hospital, Saket, Delhi
• Cytecare Cancer Hospital, Bangalore
• Amrita Hospital, Faridabad

Treating Lymphoma With CAR T At Tata Memorial Hospital, Mumbai

CAR T-cell therapy was successfully given to a patient at Tata Memorial Hospital, Mumbai, on June 4, 2021. CAR T-cell therapy. NexCAR19, approved by the Central Drugs Standard Control Organization for treating lymphoma in Octobe3 2023 is available at this hospital for lymphoma patients.

The main oncologists involved in using this treatment include:

• Dr. Gaurav Narula – Dr. Narula is a Professor of Pediatric Oncology & Health Sciences. He worked with the Indian Navy before for around 25 years. Dr. Narula’s focus is on improving lymphoma treatment outcomes with cost-effective therapies and technology like CAR T-cells.
• Dr. Navin Khattry – Dr. Khattry is the deputy director of the Advanced Centre for Treatment, Research, and Education in Cancer. Before this, he was the Assistant Professor of Medical Oncology. Dr. Khattry has been deeply associated with using the latest advancements to stop the progress of cancers like lymphoma.
• Dr. Rajendra Badwe – He is a surgical oncologist with 39 years of experience and has been involved in using CAR T-cell therapy for treating lymphoma and leukemia for the past 4 years.
• Dr. Jyoti Bajpai – She is a Professor at Tata Memorial Cancer Center. She has been researching immune-oncology and CAR T-cell therapy for the past five years. Currently, she administers CAR T treatment for lymphoma.

CAR T-Cell Therapy To Stop Lymphoma At Apollo Cancer Centres (ACCs), Chennai

Apollo Cancer Centres has begun providing Made in India CAR-T cell therapy or NexCAR19 (Actalycabtagene autoleucel) to patients aged 15 years and above. Over 25,000 patients have been treated with this novel immunotherapy approach. The major oncologists using this therapy at Apollo include:

• Dr. T. Raja – Dr. Raja is the director of Medical Oncology at ACC and an internationally acclaimed physician. He has 20 years of experience in treating blood cancer patients of various ages.
• Dr. Revathi Raj – She is the Senior Consultant of Paediatric Haematology Oncology at ACCs, Chennai with over 21 years of experience in cancer care. She is extensively involved in the latest treatments at Apollo. These include bone marrow transplant, stem cell treatment, and CAR T-cell therapy.
• Dr. Vikas Mahajan – Dr. Mahajan is a surgical oncologist having a strong 28 years of expertise. He has been researching and treating different cell tumors, breast cancer, and gynecological cancer for decades. Recently, he has been involved in using CAR T-cell therapy for lymphoma.
• Dr. Rajaraman – Dr. Rajaram is a surgical oncologist. He 23 years of experience in providing cancer screening, treating head and neck tumors, and chemotherapy.

CAR T-Cell Therapy To Fight Lymphoma At Max Hospital, Saket, Delhi

CAR T-cell therapy was launched in Max Hospital in cooperation with ImmunoACT. ImmunoACT is an Indian company that originated at IIT Bombay. CAR T-cell therapy at Max Hospital, a multi-specialty facility in Saket has shown huge success in treating lymphoma. Clinical trials have demonstrated that some patients experience complete remission from lymphoma using this therapy. The main doctors at Max Hospital for CAR T treatment are:

• Dr. Harit Chaturvedi – He is the chairman of the Max Institute of Cancer Care. Dr. Chaturvedi has been treating cancer for 33 years. He is closely involved in using CAR T-cell therapy at Max Healthcare.
• Dr. Pramod Kumar Julka – Dr. Julka has 44 years of experience in cancer care. He is the former president of the Association of Radiation Oncologists of India. At Max, he is working to make the CAR T-cell therapy program a success for lymphoma patients.
• Dr. Atul Sharma – Dr. Sharma is the Vice Chairman of Medical Oncology at Max. He has been involved in treating cancer patients, especially lymphoma sufferers of various ages for 25 years.
• Sandeep Batra – Dr. Batra is the senior director at Max Hospital in Saket. His specialties in this domain are gynecologic oncology, uro-oncology gastrointestinal oncology, and medical oncology.

Car T-Cell Therapy To Beat Lymphoma At Cytecare Hospitals, Bangalore

Cytecare Hospitals in Karnataka also collaborated with ImmunoACT. It has made CAR-T cell therapy for lymphoma patients aged 15 and above available. If the earlier treatments of patients have failed, this therapy is a viable option. Cytecare is one of the leading hospitals in India for cancer care providing research-based treatments to Indian and international patients.

Doctors involved in CAR T-therapy for lymphoma at Cytecare include:

• Dr. Prasad Narayanan – He is the director of Medical Oncology, Haemato Oncology & Bone Marrow Transplant, at Cytecare Hospital. Previously, he worked at Dubai Hospital, Mazumdar-Shaw Cancer Centre, and Narayana Health City. He was recognized with the Dronacharya Award for Oncology. At present, he is deeply involved in boosting clinical paradigms using CAR T-cell treatment.
• Dr. Akshay Kudpaje – He is the director at Head & Neck Oncology. He has been caring for cancer patients suffering from oral and laryngeal cancers. Dr. Kudpae is also a member of The Foundation for Head & Neck Oncology India and is associated with using the CAR T treatment for lymphoma.
• Dr. Aparna Subraya Gangoli – Dr. Aparna is the head of Laboratory Medicine. She is a skilled surgical oncopathologist and cytopathologist at this hospital. Dr. Gangoli is also one of the major doctors associated with the novel CAR T-cell therapy at Cytecare Hospitals for Lymphoma.
• Dr. Adithya V Naragund – Dr. Naragund is the senior GI and HBP surgery consultant. He is deeply involved in researching bone marrow and CAR T-therapy cancer treatments. Dr. Naragund also has expertise in robotic surgery and laparoscopic surgery.

CAR T-Cell Therapy To Defeat Lymphoma At Amrita Hospital, Faridabad

Amrita Hospital in Faridabad has become the first in Northern India to offer CAR T-cell treatment to lymphoma patients. A  multi-specialty hospital, it offers high-quality cancer treatments to both Indian and international patients. The hospital has administered CAR T-cell therapy to four patients and their progress is being monitored.

• Dr. Prashant Mehta – Dr. Mehta is a noted medical oncologist at Amrita Hospital who treats cancers like lymphoma. He is leading the cellular therapy program at Amrita Hospital and working to make CAR-T cell therapies more accessible.
• Dr. Sanjeev Singh – Dr. Sing is the medical director at this hospital. He has been working to improve CAR T-cell therapy for lymphoma and create a collaborative cell therapy lab.
• Dr. Pravas Chandra Mishra – Dr. Mishra is a leading hematologist at Amrita Hospital who heads the Medical Oncology department. Dr. Mishra is associated with providing stem cell transplants and CAR T-cell therapy for lymphoma.

How Much Is CAR T-Cell Treatment For Lymphoma In Turkey

The estimated overall cost of CAR T-cell therapy in Turkey for lymphoma is $1,65,875. This table will help you understand the cost breakdown clearly.

Where Is CAR T-Cell Therapy For Lymphoma Available In Turkey

The following hospitals in Turkey are providing CAR T-cell therapy for lymphoma.

• Liv Hospital
• Acibadem Altunizade Clinic
• Medipol Hospital
• Medical Park Hospital
• Anadolu Medical Center

CAR T-Cell Therapy At Liv Hospital, Istanbul

Liv Hospital in Istanbul has robust oncology, robotic surgery, and stem cell therapy departments for treating lymphoma, leukemia, and multiple myeloma. The hospital has been recognized for offering CAR T-cell therapy to lymphoma patients. The following doctors are involved in this advanced treatment approach.

• Prof. Dr. Duygu Derin – Dr. Derin is a medical oncologist with over three decades of experience. She is an active member of the Medical Oncology Society and the Chamber of Medicine. Dr. Derin has been working to provide CAR T-cell therapy for lymphoma sufferers at Liv Hospital.
• Dr. Meltem Topalgökçeli Selam – Dr. Selam is a specialist in gastrointestinal and ovarian cancer with 16 years of experience. Currently, she performs the latest procedures for treating patients, such as chemotherapy, stem cell transplantation, and CAR T-cell therapy for lymphoma.
• Dr. Merdan Fayda – Dr. Mersan has 23 years of experience. He treats patients with skin, blood, breast, and central nervous system cancers. He has also been involved in supervising lymphoma patients getting CAR T-cell therapy

CAR T-cell Therapy To Win Against Lymphoma At Acibadem Altunizade Clinic

Acibadem Altunizade Clinic provides highly individualized CAR T-cell therapy for lymphoma. Doctors use the CD-19 receptor in this treatment. It benefits those with relapsed or refractory non-Hodgkin lymphoma.

Acibadem Altunizade Clinic caters to international patients. The medical services of this clinic are globally competitive and integrated. The center uses a multidisciplinary approach and advanced technology to treat lymphoma. The following doctors are involved in developing the CAR T-cell therapy for blood cancer here.

• M.D. Abdullah Buyukcelik – Dr. Buyukcelik leads the Internal Medicine Department of Oncology at Acibadem Health Group in Turkey. He has 24 years of experience. He is also an active member of many medical associations like the Association of Internal Medicine, Medical Oncology Association, and Ankara Medical Oncology Association.
• Dr. Aziz Yazar – Dr. Yazar is the most sought-after doctor at Acobadem in Istanbul, Turkey as he has over three decades of experience. Dr. Yazar, who has previously worked at the American Hospital and the Istanbul University Institute of Oncology is also associated with delivering CAR T treatment for lymphoma.
• Dr. Alpar Sonkaya – Dr. Sonkaya is a top oncologist at Acıbadem Health Group who has previously worked at Ümraniye Training and Research Hospital. Dr. Sonkaya is also a part of the Turkish Medical Association Istanbul Medical Chamber, the European Society of Medical Oncology, and the American Society of Clinical Oncology.
• Dr. Basak Oyan Uluc – Dr. Uluc is a specialized medical oncologist. She is currently creating preventive measures programs for cancer patients using an interdisciplinary approach. It considers pathology, and therapy. She has also been involved in CAR T-cell therapy for lymphoma patients.

CAR T-Cell Treatment For Lymphoma At Medipol Mega University Hospital

The Medipol Mega University Hospital in Turkey is well-recognized in the field of cancer care with its multidisciplinary approach and cutting-edge infrastructure. Its oncological department receives over lakh cancer patients every year.

The hospital provides budget-friendly medical services. Lately, it has started providing CAR T cell therapy besides stem cell transplantation for lymphoma patients. The following doctors are administering this treatment.

• Prof. M.D. Kursat Ozdilli – Prof. Ozdilli heads the pediatric hematology and oncology department at Medipol Hospital in Turkey. He has over two decades of experience in blood cancer research and care. Dr. Ozdilli is working to develop the current state of CAR T cell therapy for lymphoma.
• M.D Hakan Kocar – Dr. Hakan Kosar is a general practitioner at Medipol Mega University Hospital. He is highly specialized in medical oncology. Dr. Kocar has a robust 26 years of experience in delivering quality care for myeloma and lymphoma patients.
• Dr. Ertan Taskopru – Dr. Taskopru, a graduate of Uludag University, is a top oncologist at Medipol Hospital. He is actively involved in the development of lymphoma treatments using CAR T cells.

Medical Park Group In Istanbul For CAR T-Cell Therapy

Medical Park Hospital in Turkey offers CAR T-cell therapy for lymphoma. It is done by a team of hematologists, oncologists, and paramedical staff. Patients can also use video telemedicine consultations before undergoing this treatment.

• Dr. Savaş Tuna – With 30 years of experience, Dr. Tuna is a top medical oncologist in Turkey’s Medical Park Hospital. He specializes in chemotherapy, immunotherapy, and CAR T-cell therapy for lymphoma patients.
• Dr. Ilan Gil Ron – Dr. Ron is a radiation oncologist with 32 years of experience. He is a member of the Israeli Society for Clinical Oncology and Radiation. Dr. Ron is deeply involved in improving lymphoma patient outcomes using CAR T-cell therapy.
• A.Uğur Yılmaz M.D. – Dr. Yilmaz has 20 years of experience in treating skin cancer and blood cancer like lymphoma and leukemia. He is well-known for using current research in treating patients at Medical Park Hospital in Istanbul.

Beat Lymphoma At Anadolu Medical Center, Istanbul

Anadolu Medical Center in Istanbul is another major provider of CAR T-cell therapy for lymphoma. The center is JCI-accredited and uses American treatment standards at affordable prices for international patients.

Anadolu Medical Center is affiliated with Johns Hopkins Hospital. It is regarded as the second-best hospital globally as per the Medical Travel Quality Alliance (MTQUA). The major medical oncologists involved in providing CAR T-cell therapy for lymphoma at Anadolu are:

• MD Zafer Gulbas – At Anadolu Medical Center, Dr. Gulbas serves as the director of medical oncology. The Bone Marrow Transplantation Center was established by him. CAR T-cell therapy for lymphoma is administered by Dr. Gulbas. In addition to this treatment, patients receive airport transfers and language support.
• Dr. Savas Kansoy – A pediatric oncologist and hematologist, Dr. Kansoy is a member of numerous associations for medical oncology. He is currently trying to improve the results of lymphoma treatment using CAR T cells.

• Dr. Serdar Turhal – Dr. Turhal specializes in various medical oncology procedures. Previously, he was the lead member of the Oncology Department of the European Medical Association in 2015. He is abreast of the advancements in cancer treatments like immunotherapy and CAR T-cell therapy for lymphoma.
• Dr. Seref Komurcu – Dr. Komurcu has experience in working at prestigious hospitals like Cleveland Clinic in the USA. He has been a member of the Pharmacovigilance Commission and Oncology Advisory Commission. At Anadolu Medical Center, Dr. Komurcu is associated with delivering the CAR T-cell therapy program for lymphoma.

How Expensive Is CAR T-Cell Therapy for Lymphoma In Singapore?

CAR T-cell therapy’s price for lymphoma in Singapore is $4,30,630. This table shows the breakdown.

CAR T-Cell Therapy Hospitals And Doctors In Singapore

In Singapore, CAR T-cell therapy for lymphoma is being provided at the following facilities

• Centre for Clinical Haematology (CFCH)
• National Cancer Centre (NCC)
• Parkway Cancer Centre (PCC)
• Singapore General Hospital

CAR T-Cell Therapy For Non-Hodgkin Lymphoma At CFCH

Centre For Clinical Haematology (CFCH) is a prominent haematology centre in Asia. Its clinics at Mount Elizabeth Novena Specialist Centre and Gleneagles Hospital provide CAR T-cell therapy for lymphoma. The hospital has insurance partners for patients to cover their treatment expenses. Patients who have failed prior blood cancer treatment approaches are eligible for this therapy.

• Dr. Lim Zi Yi – Dr. Yi is a senior consultant and has a deep expertise in Haematopoietic stem cell transplantation and CAR T-cell therapy for lymphoma. He has over 20 years of experience researching and working at various hematology centres in London and Singapore.
• Dr. Ng Chin Hin – Dr. Hin Leukaemia was the head of the National University Cancer Institute of Singapore. He works as a senior consultant at CFCH. He has been developing novel lymphoma and leukemia treatments for over 20 years.

Beat Lymphoma With CAR T-Cell Therapy At National Cancer Centre

In Southeast Asia, Singapore’s National Cancer Center is another top choice for Lymphoma patients who want to undergo CAR T-cell therapy. The center conducts cutting-edge clinical trials. It has partnerships with preeminent research institutions worldwide. With cutting-edge resources and a multispecialty group of professionals, the National Cancer Center is today a major place for CAR T-cell therapy innovation.

The oncologists involved in this treatment here include:

• Assoc Prof Ravindran Kanesvaran – Dr. Kanesvaran is the chairman at the National Cancer Centre Singapore. He is an acclaimed medical oncologist with a special interest in treating lymphoma through CAR T-cell therapy.
• Assoc Prof Tham Chee Kian – Dr. Kian treats brain, skin, and stomach malignancies. He is the deputy chairman of the Medical Oncology at the National Cancer Centre Singapore. He is deeply involved in improving CAR T-cell therapy for lymphoma patients.
• Assoc Prof Ang Mei-Kim – Dr. Kiem is a senior consultant of the Medical Oncology division at the National Cancer Centre Singapore. She is involved in many ongoing clinical trials and research related to boosting outcomes using CAR T-cell therapy for lymphoma.
• Asst Prof Chay Wen Yee – Dr. Yee is a senior medical oncologist at NCC. She is also a consultant of the Department of Gynecological Oncology, KK Women and Children’s Hospital. She is supervising many trials and projects on lymphoma treatments.

Parkway Cancer Centre For CAR T-Cell Therapy

Parkway Cancer Centre is the first private institution in Singapore to offer CAR T-cell therapy for lymphoma. This innovative treatment has proven successful for many patients. The remission rates of these patients were  between 60–80%.

PCC started offering CAR T-cell after it received an approval from the Singapore Health Sciences Authority (HSA) under a new regulatory framework for Cell, Tissue, and Gene Therapy Products.

Patients are given personalized CAR T-cell therapy for lymphoma. It is sometimes administered with an allogeneic stem cell transplant. The major medical oncologists involved in this treatment include:

• Dr. Ang Peng Tiam – Dr. Tiam is the medical director at PCC. He has three decades of experience in providing blood cancer care. He is one of the chief figures associated with CAR T-cell therapy for lymphoma at Parkway.
• Dr. Khoo Kei Siong – He is the senior consultant at PCC. Dr. Siong is a part of many medical organizations. These include the American Society of Clinical Oncology and the European Society of Medical Oncology.
• Dr. Teo Cheng Peng – Dr. Peng specializes in treating lymphoma and stem cell transplants. He is the founder of the Stem Cell Transplant service at the National University Hospital. Currently, his research efforts are for using CAR T-cell therapy for lymphoma patients at Parkway.
• Dr. Dawn Mya Hae – Dr. Hae is the senior consultant at Parkway Cancer Centre. She specializes in treating blood diseases like leukemia and lymphoma using immunotherapy approaches like CAR T.

Beating Lymphoma With CAR T-Cell Therapy At Singapore General Hospital

Chimeric Antigen Receptor (CAR) T cell therapy for non-Hodgkin’s lymphoma is available at the Singapore General Hospital (SGH). It is provided in collaboration between Duke-NUS Medical School, Singapore, and SGH.

Mr. Tan Chee Mun was Singapore’s first patient to undergo this treatment. The hospital provides this therapy to lymphoma patients who have already undergone standard treatments. The key medical oncologists involved in administering CAR T at SGH are:

• Dr. Nicholas Grigoropoulos – He is a senior consultant at Singapore General Hospital. He has been working for a long period at SGH to treat lymphoma with CAR T-cell therapy.
• Dr. Francesca Lorraine Lim – Dr. Lim is the Chief Medical Officer at the Advanced Cell Therapy and Research Institute Singapore (ACTRIS). She has undergone extensive training in CAR T-cell therapy for lymphoma under Professor Katy Rezvani at MD Anderson Cancer Center.

What Is The Cost Of CAR T-Cell Therapy In Israel

CAR T-cell therapy for lymphoma in Israel’s best hospitals costs around $ 1,69,790. This cost is divided into the following elements.

Hospitals And Doctors In Israel For CAR T-Cell Therapy

CAR T-cell therapy for lymphoma is being offered at the following hospitals:

• Hadassah Hospital
• Sheba Medical Center

Hadassah Hospital’s Affordable CAR T-Cell Therapy For Lymphoma

The innovative immunotherapy treatment known as CAR T-cell therapy for lymphoma is now available at reasonable costs thanks to the Hadassah Medical Organization in Jerusalem.

At Israel’s Weizmann Institute of Science, Zelig Eshhar, PhD, came up with the concept to employ this treatment. The CAR-T therapy for leukemia and myeloma was created by Prof. Polina Stepensky, Dr. Shlomit Kfir-Erenfeld, and Dr. Nathalie Asherie of the bone marrow transplantation department at Hadassah Hospital. They achieved this through working with Bar-Ilan University professor Cyrille J. Cohen.

Patients using NEXICART-1 are being treated at the hospital (NCT04720313). The US will see an increase in its clinical testing. This therapy has produced positive results three times so far. At Hadassah, the principal physicians utilizing this treatment are:

• Dr. Polina Stepensky – Dr. Stepensky is the head of the Department of TKM and Immunotherapy in Children and Adults at Hadassah Hospital. She introduced CAR T treatment for lymphoma in Israel. Her efforts have resulted in a cost-effective approach to using it.
• Dr. Tamar Peretz-Yablonski – Dr. Tamar is an oncology specialist. She has 40 years of experience and heads the Sharett Institute of Oncology in Hadassah University Hospital. She is also testing and providing CAR T-cell therapies to lymphoma patients.
• Dr. Vivian Barak – Dr. Barak specializes CAR T-cell therapy for lymphoma and multiple myeloma. She also teaches at the Hadassah University Medical Center. Dr. Barak has 40 years of experience in developing cutting-edge treatments for cancer patients.

Sheba Medical Center Making CAR T-Cell Therapy For Lymphoma Accessible

In Israel, CAR T-cell therapy for lymphoma is also available at Sheba Medical Center. It is led by the Ella Lemelbaum Institute for Immuno-Oncology and the Pediatric Hemato-Oncology Department. CAR T-cell therapy for leukemia has a success rate of 70–85% in the general population and 80–85% in children and teenagers at Sheba Hospital. The T-cells are created internally.

The hospital is independent of commercial pharmaceutical producers. To maintain the potency and quality of the cell, this is done. Thus far, this innovative treatment for blood cancer has been administered to patients from Brazil, Cyprus, Ireland, Italy, Russia, South Africa, Serbia, India, and Ukraine.
The CAR-T programs at the hospital were launched in 2016. This immunotherapy has been given to 258 patients so far.

Sheba is now among the biggest CAR-T cell therapy facilities in Europe as a result. It usually takes about ten days for patients to receive this treatment. A two-week hospital stay for observation and rehabilitation comes next. Oncologists tailor each patient’s treatment according to their unique needs and medical history. Leading oncologists taking part in this initiative include:

• Dr. Arnon Nagler: He oversees the Chaim Sheba Medical Center’s hematology, bone marrow transplantation, and cord blood bank departments. Dr. Nagler has twenty-five years of experience. He is an expert in the fields of transplantation and cell-mediated immunotherapy. He is currently treating lymphoma patients from all over the world at Sheba Hospital with CAR T-cell therapy.
• Dr. Avigdor – The Israeli Lymphoma Working Group was founded by Dr. Avigdor. For his work in hematology, he has won numerous awards. He treats lymphoma patients with cutting-edge treatment techniques. Among the various methods he employs for Sheba patients is CAR T-cell therapy.
• Dr. Elad Jacoby – Dr. Elad is skilled in treating lymphoma with stem cell and CAR T-cell transplants. He is in charge of the pediatric cell therapy center in Sheba. Additionally, the Pediatric Hematology and Oncology has certified him.

Cost Of CAR T-Cell Therapy For Lymphoma In Spain

In Spain, CAR T-cell therapy for Lymphoma has an estimated cost of $3,21,620. Here’s the estimated price of various aspects of this treatment.

CAR T-Cell Therapy Hospitals And Doctors In Spain

The novel CAR T-cell treatment for lymphoma is available in the following hospitals in Spain.

• Hospital Clinic de Barcelona
• Hospital Universitario 12 de Octubre in Madrid
• Vall d’Hebron University Hospital in Barcelona

Fighting Lymphoma Successfully At Hospital Clinic de Barcelona

Hospital Clínic in Barcelona-IDIBAPS has shown that CAR T-cell therapy ARI0002h is effective for non-Hodgkin lymphoma patients who are not responding to other treatments. Patients aged 25 years and older can get this therapy.

The ARI-0001 at Hospital Clinic de Barcelona is more inexpensive than commercially produced CAR T-cell therapies. Moreover, it has given complete responses in more than 70% of cases. The major doctors involved in providing it include;

• Dr. Carlos Fernández de Larrea – Dr. Larrea is an award-winning hematologist who has been participating actively in clinical trials for blood cancers. Dr. Larrea is also supervising the CAR T-cell therapy treatment for lymphoma at Hospital Clínic in Barcelona.
• Dr. Manel Juan – Dr. Juan is the head of the Immunology Service at the Hospital Clínic. He is a researcher in the fields of Immunogenetics and immunotherapy. Currently, he is developing CAR T-cell therapy to treat lymphoma.

Hospital Universitario 12 de Octubre in Madrid For CAR T-Cell Therapy

Hospital Universitario 12 de Octubre in Madrid has also started providing CAR T-cell therapy for B-cell lymphoma (DLBCL). Advanced CAR-T therapies are also given to patients who do not respond to chemotherapy or other treatments.

On October 12, 2022, this therapy was administered to several patients. All of them achieved a complete positive response. They tested negative for the disease. Patients can use their insurance coverage to pay for this treatment. The following oncologists are administering CAT T to lymphoma patients at Hospital Universitario:

• Dr. Luis Paz-Ares – He is the head of the Medical Oncology Service at Hospital Universitario. He is also a part of the Faculty of Medicine of the Complutense University of Madrid. Dr. Ares has been acknowledged by Forbes for his efforts to improve cancer care in Spain.
• Dr. Luis Álvarez-Vallina – Dr. Vallina is a member of the Cancer Immunotherapy Unit at Hospital Universitario 12 de Octubre. He has been studying and administering CAR T-cell therapy for lymphoma through trials.

CAR T-Cell Therapy For Lymphoma At Vall d’Hebron University Hospital in Barcelona

CAR T-cell therapy treatment for lymphoma is available at Vall d’Hebron University Hospital in Barcelona. The hospital received 2.6 million euros for research into CAR-T cells. This shows how committed the hospital is to advancing novel immunotherapy approaches.

A unique platform developed by Vall d’Hebron Institute of Oncology (VHIO) shows promise in producing superior CAR T-cell therapy. It is expected to reduce the production time significantly.

The major doctor involved in CAR T treatment at Vall d’Hebron University Hospital is Dr. Pere Barba. He is the director of the CAR-T Program at the Vall d’Hebron University Hospital. He has been using trials with this therapy on patients with lymphoma.