high cholesterol

What is high cholesterol?

Cholesterol is a waxy, fatlike substance that your liver produces. It’s vital for the formation of cell membranes, vitamin D, and certain hormones. Cholesterol doesn’t dissolve in water, so it can’t travel through the body by itself.

Particles known as lipoproteins help transport cholesterol through the bloodstream. There are two major forms of lipoproteins.

Low-density lipoproteins (LDL), also known as “bad cholesterol,” can build up in the arteries and lead to serious health problems, like heart attack or stroke.

High-density lipoproteins (HDL), sometimes called “good cholesterol,” help return the LDL cholesterol to the liver for elimination.

Eating too many foods that contain high amounts of fat increases the level of LDL cholesterol in your blood. This is known as high cholesterol, also called hypercholesterolemia or hyperlipidemia.

If levels of LDL cholesterol are too high, or levels of HDL cholesterol are too low, fatty deposits build up in your blood vessels. These deposits will make it difficult for enough blood to flow through your arteries. This could cause problems throughout your body, particularly in your heart and brain, or it could be fatal.

What are the symptoms of high cholesterol?

High cholesterol typically doesn’t cause any symptoms. In most cases it only causes emergency events. For instance, a heart attack or stroke can result from the damage caused by high cholesterol.

These events typically don’t occur until high cholesterol leads to the formation of plaque in your arteries. Plaque can narrow arteries so less blood can pass through. The formation of plaque changes the makeup of your arterial lining. This could lead to serious complications.

A blood test is the only way to know if your cholesterol is too high. This means having a total blood cholesterol level above 240 milligrams per deciliter (mg/dL). Ask your doctor to give you a cholesterol test after you turn 20 years old. Then get your cholesterol rechecked every 4 to 6 years.

Your doctor may also suggest you have your cholesterol checked more frequently if you have a family history of high cholesterol. Or if you demonstrate the following risk factors:

  • have high blood pressure
  • are overweight
  • smoke

Genetic conditions

There is a condition passed through genes that causes high cholesterol called familial hypercholesterolemia. People with this condition have cholesterol levels of 300 mg/dL or higher. They may experience xanthoma, which can appear as a yellow patch above the skin, or a lump underneath the skin.

Coronary artery (heart) disease

Symptoms of heart disease may be different for men and women. However, heart disease remains the number one killer of both sexes in the United States. The most common symptoms include

  • angina, chest pain
  • nausea
  • extreme fatigue
  • shortness of breath
  • pain in the neck, jaw, upper abdomen, or back
  • numbness or coldness in your extremities
  • Stroke

The buildup of plaque caused by high cholesterol can put you at serious risk of having the blood supply to an important part of your brain reduced or cut off. This is what happens when a stroke occurs.

A stroke is a medical emergency. It’s important to act fast and seek medical treatment if you or anyone you know experiences the symptoms of a stroke. These symptoms include:

  • sudden loss of balance and coordination
  • sudden dizziness
  • facial asymmetry (drooping eyelid and mouth on just one side)
  • inability to move, particularly affecting just one side of the body
  • confusion
  • slurring words
  • numbness in the face, arm, or leg, especially on one side of the body
  • blurred vision, blackened vision, or double vision
  • sudden severe headache

Heart attack

The arteries that supply the heart with blood can slowly narrow due to the buildup of plaque. This process, called atherosclerosis, happens slowly over time and has no symptoms. Eventually, a piece of the plaque can break off. When this happens, a blood clot forms around the plaque. It can block blood flow to the heart muscle and deprive it of oxygen and nutrients.

This deprivation is called ischemia. When the heart becomes damaged, or part of the heart begins to die due to the lack of oxygen, it’s called a heart attack. The medical term for a heart attack is myocardial infarction.

Signs of a heart attack include:

  • tightness, squeezing, fullness, pain, or aching in the chest or arms
  • difficulty breathing
  • anxiety or an a feeling of impending doom
  • dizziness
  • nausea, indigestion, or heartburn
  • excessive fatigue

A heart attack is a medical emergency. Damage to the heart could be irreversible, or even fatal, if treatment doesn’t begin in the first several hours after a heart attack.

It’s important to act fast and seek medical treatment if you or anyone you know experiences the symptoms of a heart attack.

Peripheral arterial disease

Peripheral artery disease (PAD) can occur when plaque builds up in the walls of the arteries. This will block the flow of blood in the arteries that supplies blood to the kidneys, arms, stomach, legs, and feet.

Symptoms of early PAD may include:

  • cramping
  • achiness
  • fatigue
  • pain in the legs during activity or exercise, called intermittent claudication
  • discomfort in the legs and feet

As PAD progresses, symptoms occur more frequently and even occur when you are at rest. Later symptoms that may occur because of reduced blood flow include:

  • thinning, paleness, or shininess on the skin of the legs and feet
  • tissue death caused by lack of blood supply, called gangrene
  • ulcers on the legs and feet that don’t heal or heal very slowly
  • leg pain that doesn’t go away when at rest
  • burning in your toes
  • leg cramps
  • thick toenails
  • toes that turn blue
  • reduced hair growth on the legs
  • decrease in the temperature of your lower leg or foot, compared to the other leg

People with PAD have a higher risk of having a heart attack, stroke, or limb amputations.


High cholesterol is very easy to diagnose with a blood test called a lipid panel. Your doctor will take a sample of blood and send it to a laboratory for analysis. Your doctor will ask that you do not eat or drink anything for at least 12 hours prior to the test.

A lipid panel measures your total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides. The Centers for Disease Control and Prevention (CDC) says these are the desirable levels:

  • LDL cholesterol: less than 100 mg/dL
  • HDL cholesterol: 60 mg/dL or higher
  • triglycerides: less than 150 mg/dL

Your total cholesterol is generally considered “borderline high” if it’s between 200 and 239 mg/dL. It’s considered “high” if it’s above 240 mg/dL.

Your LDL cholesterol is generally considered “borderline high” if it’s between 130 and 159 mg/dL. It’s considered “high” if it’s above 160 mg/dL.

Your HDL cholesterol is generally considered “poor” if it’s below 40 mg/dL.

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